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( A) The stages of the life cycle of an autophagosome. ( B) Model for the role of local fatty acid (FA) activation, de novo phospholipid (PL) synthesis, and Atg2-mediated PL transfer during phagophore expansion. ACS, acyl-coenzyme A synthetase; CoA, coenzyme A; ERES, endoplasmic reticulum exit site.
