Kolomainen 2012.
Methods | Retrospective review | |
Participants | 90 women with relapsed epithelial ovarian cancer who underwent palliative surgery for bowel obstruction 1992 to 2008: both elective and emergency (surgery within 24 hours of decision to operate) | |
Interventions | Gastrostomy 19/90 (alone 15/90, as part of procedure 4/90); bypass +/‐ stoma 5/90; stoma 56/90; anastomosis 17/90; bowel resection 22/90 No conservative treatment |
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Outcomes | "Successful palliation" as independent of IV fluids and adequate oral intake at 60 days postoperative: overall 66% (59/90); emergency 69% (34/49); elective 63% (25/40) Postoperative mortality: overall 18% (16/90); emergency 20% (10/49); elective 15% (6/40) Postoperative morbidity rate: 27% (24/90); return to operating room 2/90; high‐output stoma 9/90; retraction of stoma 3/90; parastomal abscess 1/90; superficial wound breakdown 2/90; wound infection 3/90; wound dehiscence 2/90; prolonged ileus 1/90; intra‐abdominal/sub‐sheath collections 1/90; medical complications 5/90 Median overall survival: 90.5 days (< 1 day to 6 years) Re‐obstruction rate: 10 patients further obstructed and no further surgery |
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Notes | Unclear outcome 1 patient | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | High risk | No allocation. All patients included in study underwent surgery. "Indication of surgery was based on clinical findings of an acute abdomen, failure of bowel obstruction to resolved following a period of conservative management." |
Allocation concealment (selection bias) | High risk | No blinding. All patients included in study underwent surgery. Outcomes identified from review of notes made by clinicians at time of treatment |
Blinding (performance bias and detection bias) All outcomes | High risk | No blinding. All patients included in study underwent surgery. Outcomes identified from review of notes made by clinicians at time of treatment |
Blinding of participants and personnel (performance bias) All outcomes | High risk | No blinding. All patients included in study underwent surgery. Outcomes identified from review of notes made by clinicians at time of treatment |
Blinding of outcome assessment (detection bias) All outcomes | High risk | No blinding. All patients included in study underwent surgery. Outcomes identified from review of notes made by clinicians at time of treatment |
Selective reporting (reporting bias) | Unclear risk | Unclear outcome 1 patient Results not reported according to surgical intervention Symptoms not included in "successful palliation" |