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. 2020 Feb 27;5(4):e131018. doi: 10.1172/jci.insight.131018

Figure 1. Deep immunophenotyping revealed striking loss of most, but not all, HSCs and progenitors in bone marrow from patients with FA/SDS.

Figure 1

(A) Analytic strategy of bone marrow aspirate cells by immunophenotyping. (B and C) Comparison of multipotent cells between FA (n = 6), SDS (n = 7), and control (n = 8). The mean percentage of HSPCs among the viable bone marrow mononuclear cells is presented with SEM. (D and E) Comparison of oligopotent progenitors between FA, SDS, and control patients. The mean percentage of HSPCs among the viable bone marrow mononuclear cells is presented with standard error of the mean (SEM). PI, propidium iodide; Flt3, FMS-like tyrosine kinase 3; CMP, common myeloid progenitor; GMP, granulocyte-monocyte progenitor; MEP, megakaryocyte erythroid progenitor; HSC, hematopoietic stem cell; MLP, multilymphoid progenitor; MPP, multipotent progenitor. Student’s t test was used to compare between patients and controls. The same control data in C and E are also presented in B and D, respectively.