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. 2020 Feb 27;5(4):e131018. doi: 10.1172/jci.insight.131018

Figure 4. Patterns of single nucleotide and trinucleotide alterations in FA/SDS-associated AML.

Figure 4

(A) Mutation rate in FA/SDS patients with AML or without AML. (B) Percentage of each type of transition mutation across FA/SDS patients with or without AML samples. Percentages of transversions are in Supplemental Figure 19. (C) Trinucleotide heatmap of patients with FA, FA/AML, SDS, and SDS/AML. The trinucleotide mutations are shown with the 5′ base on the y axis and the 3′ base on the x axis. (D) Types of mutations in AML versus non-AML samples. The box plots depict the minimum and maximum values (whiskers), the upper and lower quartiles, and the median. The length of the box represents the interquartile range.