Figure 6. Blockade of PAPP-A function with monoclonal antibody (mAb-PA) decreases cyst formation in ADPKD mice.

Pkd1^RC/RC mice were treated with mAb-PA (30 mg/kg) or vehicle once per week for 6 weeks. (A) Representative images of H&E-stained kidney sections and graphs showing kidney size and percent cystic area; age, 7.5 months (n = 9–12). Scale bars: 2000 μm. (B) BUN measurements in vehicle (n = 5) and anti–PAPP-A–treated mice (n = 5). (C) Mcp1, Ngal, Col1a1, and Tgfb mRNA expression in vehicle or mAb-PA–treated Pkd1^RC/RC mice (n = 7–9). Data are mean ± SEM. A *P < 0.05, **P < 0.01 by 2-tailed Student’s t test.