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. 2020 Mar 16;26:e921611-1–e921611-7. doi: 10.12659/MSM.921611

Figure 1.

Figure 1

The schematic view of ESR1 and ESR2 missense variants. (A, B) Diagram of ESR1/2 domains with the locations of the identified missense variants. AF-1 – activation function-1; DBD – DNA-binding domain; NLS – nuclear localization signal; LBD – ligand-binding domain; AF-2 – activation function-2. (C) Space distribution of missense variant in the NLS domain in ESR1 protein. The model of ESR1 protein (182–545 amino acids) was built by Swiss-Model (https://www.swissmodel.expasy.org/). The de novo missense variant (c.868A>G, p.Asn290Asp, red) was located close to the DNA-binding region.