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. Author manuscript; available in PMC: 2021 Mar 25.
Published in final edited form as: Chem Rev. 2019 Nov 27;120(6):3051–3126. doi: 10.1021/acs.chemrev.9b00450

Figure 34.

Figure 34.

Semisynthesis applied to histone H3. a) Semisynthesis of H3Ser10ph through NCL, and incorporation into nucleosome arrays (Shogren-Knaak et al.).498 b) Traceless semisynthesis of polyacetylated H3 using NCL and desulfurization (He et al.).161 c) Traceless semisynthesis of H3 by sortase-mediated ligation using the F40 sortase.