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. Author manuscript; available in PMC: 2021 Mar 25.
Published in final edited form as: Chem Rev. 2019 Nov 27;120(6):3051–3126. doi: 10.1021/acs.chemrev.9b00450

Figure 35.

Figure 35.

Semisynthesis applied to ubiquitinated histone H2B. a) Scheme for the semisynthesis of ubiquininated histone H2B from three fragments.159 b) PTM crosstalks biochemically verified using semisynthetic ubiquitinated histone H2B.