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. Author manuscript; available in PMC: 2021 Mar 25.
Published in final edited form as: Chem Rev. 2019 Nov 27;120(6):3051–3126. doi: 10.1021/acs.chemrev.9b00450

Figure 59.

Figure 59.

Semisynthesis of the catalytic domain of sortase A (SrtA). a) Scheme for the semisynthesis of citrullinated SrtA using EPL.274 b) Molecular mechanism of transpeptidation facilitated by H-bonding between the sorting motif and Arg/Cit.