Table 3.
Background characteristics and factors collected from questionnaires obtained from prophylactically operated vs. nonoperated mutation carriers
| Reported variables | Study population (N = 76)a | Prophylactic hysterectomy performed (N = 42)b | Nonoperated (N = 24) | p valuec |
|---|---|---|---|---|
| n (%) | n (%) | n(%) | ||
| 1. Parity: 1 or more deliveries | 66 (86.8) | 37 (88.1) | 21 (87.5) | 1.000 |
| 2. Own health considered intermediate or good | 50 (65.8) | 24 (58.5) | 18 (75.0) | 0.282 |
| 3. In a relationship at mutation diagnosis | 67 (88.2) | 40 (95.2) | 19 (79.2) | 0.089 |
| 4. Attended gynecological appointments regularly | 68 (89.5) | 37 (88.1) | 21 (87.5) | 1.000 |
| 5. Cancer other than gynecological cancer in family | 73 (96.0) | 39 (92.9) | 24 (100.0) | 0.295 |
| 6. Family member died of gynecological cancer | 17 (22.3) | 12 (29.3) | 4 (16.7) | 0.373 |
| 7. Poor tolerance of feeling of insecurity | 13 (17.1) | 5 (11.9) | 5 (20.8) | 0.477 |
| 8. Strong fear of cancer | 32 (42.1) | 19 (45.2) | 10 (41.7) | 0.803 |
| 9. Strong fear of surgery/operations | 12 (15.7) | 6 (14.3) | 4 (16.7) | 1.000 |
| 10. Experience of surgery as responsibility | 16 (21.0) | 12 (29.3) | 3 (12.5) | 0.142 |
| 11. Feels/has felt pressure for surgery | 20 (26.3) | 14 (35.9) | 5 (22.7) | 0.391 |
| 12. Satisfied with information and advice in general | 43 (56.6) | 30 (73.2) | 7 (31.8) | 0.003 |
| 13. Satisfied with information on possible postoperative disadvantages | ||||
| a. Urinary complaints | 18 (23.6) | 11 (28.9) | 2 (9.1) | 0.106 |
| b. Chronic pelvic pain | 20 (26.3) | 12 (31.6) | 3 (13.6) | 0.215 |
| c. GI-tract complaints | 19 (25.0) | 12 (31.6) | 2 (9.1) | 0.061 |
| d. Pelvic prolapses | 19 (25.0) | 12 (31.6) | 2 (9.1) | 0.061 |
| 14. Endometrial biopsy pain (NRS score) | (N = 54)d | (N = 28)d | (N = 19)d | |
| a. 0–5 | 39 (72.2) | 21 (75.0) | 11 (57.9) | |
| b. 6–10 | 15 (27.8) | 7 (25.0) | 8 (42.1) | 0.339 |
| 15. Median age, years | Year (range) | Year (range) | Year (range) | |
| a. At mutation testing | 35.2 (22–65) | 42.3 (25–65) | 31.6 (22–48) | < 0.001 |
| b. At survey | 48.8 (30–76) | 56.9 (43–72) | 43.2 (30–76) | < 0.001 |
aDefined by study questionnaire responders
b10 subjects with nonprophylactic hysterectomy excluded from comparison
cComparison between nonoperated and prophylactically operated subjects
dTotal of 54 subjects answered this question (22 subjects did not respond)