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. 2019 Dec 27;47(5):1302–1313. doi: 10.1007/s00259-019-04646-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Tracer development and validation. a Graphical illustration of 6E11 chelator conjugation using endoglycosidase S2 and DIBO-DFO yielding 2 chelates per antibody on the heavy chain glycans. b HPLC chromatogram of ⁸⁹Zr-DFO-6E11. c Immuno-reactivity assay of ⁸⁹Zr-DFO-6E11 incubated with HCC827 cells (high PD-L1 expression). d Saturation binding assay of ⁸⁹Zr-DFO-6E11 incubated with HCC827 cells. CPM, counts per minute; DIBO-DFO, dibenzocyclooctyne-desferrioxamine; IRF, immuno-reactive fraction; K_D, dissociation constant