Table 6.
Predictor candidates | Derivation set (year = 2004–2012) () | Temporal validation set (year = 2013) () | |||||||
---|---|---|---|---|---|---|---|---|---|
Survival | Death | p-value* | Survival | Death | p-value* | ||||
Demographic data, mean(sd) | |||||||||
1 | Gender, n(%) | 1.0 | 1.0 | ||||||
Male | 358 | 326 (74.60) | 32 (74.42) | 43 | 40 (74.07) | 3 (0.75) | |||
Female | 122 | 111 (25.40) | 11 (25.58) | 15 | 14 (25.93) | 1 (0.25) | |||
2 | Age | 480 | 52.69 (9.18) | 47.93 (15.29) | 0.0982 | 58 | 52.63 (10.48) | 55.25 (7.72) | 0.6896 |
3 | BMI | 470 | 24.52 (3.90) | 87.00 (39.65) | 0.3626 | 57 | 26.25 (4.26) | 24.05 (2.30) | 0.2918 |
4 | Survival days | 480 | 1411.25 (1014.81) | 12.14 (7.04) | <2.2E-16 | 58 | 172.70 (76.51) | 11.75 (11.95) | 0.00097 |
Blood test of day 9, mean (sd) | |||||||||
5 | INR | 470 | 1.73 (0.85) | 2.51 (2.74) | 4.724E-06 | 56 | 1.58 (2.04) | 0.56 (0.56) | 0.07164 |
6 | Lymphocyte | 467 | 22.33 (12.31) | 18.55 (13.33) | 0.02734 | 57 | 22.14 (11.40) | 18.23 (8.87) | 0.5219 |
7 | Mg | 415 | 1.68 (0.24) | 1.65 (0.33) | 0.1257 | 50 | 1.69 (0.26) | 1.55 (0.23) | 0.3133 |
8 | Na | 268 | 137.06 (5.82) | 138.17 (10.12) | 0.9906 | 8 | 123.28 (5.91) | 122.14 (2.32) | 0.9908 |
9 | Platelets | 476 | 79.21 (49.16) | 63.39 (35.46) | 0.0814 | 57 | 81.64 (68.08) | 85.08 (18.66) | 0.2811 |
10 | WBC | 476 | 4.86 (3.26) | 5.99 (3.79) | 0.03277 | 57 | 4.83 (5.16) | 6.67 (3.56) | 0.1378 |
Preoperative status, mean(sd) | |||||||||
11 | MELD score | 480 | 17.84 (8.90) | 24.21 (9.36) | 1.617E-05 | 58 | 16.69 (10.04) | 29.75 (11.90) | 0.021 |
12 | Hepatitis, n(%) | 0.1996 | 0.2852 | ||||||
Nil | 83 | 71 (16.25) | 12 (27.91) | 19 | 16 (29.63) | 3 (0.75) | |||
Hepatitis B Virus (HBV) | 277 | 253 (57.89) | 24 (55.81) | 22 | 21 (38.89) | 1 (0.25) | |||
Hepatitis C Virus (HCV) | 96 | 90 (20.59) | 6 (13.95) | 16 | 16 (29.63) | 0 (0) | |||
Dual | 24 | 23 (5.27) | 1 (2.33) | 11 | 1 (1.85) | 0 (0) | |||
13 | HCC, n(%) | 0.004467 | 0.2002 | ||||||
No | 264 | 231 (52.86) | 33 (76.74) | 33 | 29 (53.70) | 4 (1.0) | |||
Yes | 216 | 206 (47.14) | 10 (23.26) | 25 | 25 (46.30) | 0 (0) | |||
14 | DX1, n(%) | 0.1942 | — | ||||||
Virtual hepatitis | 396 | 363 (83.26) | 33 (76.74) | 43 (79.63) | 2 (0.50) | ||||
Alcoholic cirrhosis | 35 | 32 (7.34) | 3 (6.98) | 6 (11.11) | 1 (0.25) | ||||
Wilson’s disease | 6 | 4 (0.92) | 2 (4.65) | 1 (1.85) | 0 (0) | ||||
Primary Biliary cirrhosis | 7 | 7 (1.61) | 0 (0) | 0 (0) | 0 (0) | ||||
Biliary atesia | 2 | 1 (0.23) | 1 (2.33) | 0 (0) | 0 (0) | ||||
Fulminiant hepatitis | 4 | 3 (0.69) | 1 (2.33) | 0 (0) | 0 (0) | ||||
Secondary Biliary cirrhosis | 1 | 1 (0.23) | 0 (0) | 0 (0) | 0 (0) | ||||
Other malignancy | 2 | 2 (0.46) | 0 (0) | 0 (0) | 0 (0) | ||||
Others | 26 | 23 (5.26) | 3 (6.98) | 4 (7.41) | 1 (0.25) | ||||
Other details, mean(sd) | |||||||||
15 | Graft-recipient weight ratio (GRWR, %) | 387 | 1.01 (0.24) | 1.03 (0.48) | 0.4077 | 53 | 0.94 (0.2) | 1.02 (0.23) | 0.5004 |
16 | Liver weight | 413 | 633.15 (146.82) | 520.61 (134.30) | 50 | 644.68 (129.73) | 620 (256.60) | 0.8381 | |
17 | Types of liver transplant, n(%) | 0.03325 | 0.7745 | ||||||
Living donor | 414 | 382 (87.41) | 32 (74.42) | 54 | 51 (94.44) | 3 (0.75) | |||
Deceased donor | 66 | 55 (12.59) | 11 (25.58) | 4 | 3 (5.56) | 1 (0.25) |