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. 2020 Mar 27;10:5654. doi: 10.1038/s41598-020-62387-z

Table 6.

Patients’ characteristics at 9 days before the surgery in derivation and temporal validation sets. The characteristics comprise basic information, blood test, preoperative status and other details. Moreover, statistical tests are applied to the data. *Mann-Whitney U Test were performed for continuous data, and Pearson Chi-Squared Tests for categorical data between groups comparison.

Predictor candidates Derivation set (year = 2004–2012) (n=480) Temporal validation set (year = 2013) (n=58)
n Survival (n=437) Death (n=43) p-value* n Survival (n=54) Death (n=4) p-value*
Demographic data, mean(sd)
1 Gender, n(%) 1.0 1.0
Male 358 326 (74.60) 32 (74.42) 43 40 (74.07) 3 (0.75)
Female 122 111 (25.40) 11 (25.58) 15 14 (25.93) 1 (0.25)
2 Age 480 52.69 (9.18) 47.93 (15.29) 0.0982 58 52.63 (10.48) 55.25 (7.72) 0.6896
3 BMI 470 24.52 (3.90) 87.00 (39.65) 0.3626 57 26.25 (4.26) 24.05 (2.30) 0.2918
4 Survival days 480 1411.25 (1014.81) 12.14 (7.04) <2.2E-16 58 172.70 (76.51) 11.75 (11.95) 0.00097
Blood test of day 9, mean (sd)
5 INR 470 1.73 (0.85) 2.51 (2.74) 4.724E-06 56 1.58 (2.04) 0.56 (0.56) 0.07164
6 Lymphocyte 467 22.33 (12.31) 18.55 (13.33) 0.02734 57 22.14 (11.40) 18.23 (8.87) 0.5219
7 Mg 415 1.68 (0.24) 1.65 (0.33) 0.1257 50 1.69 (0.26) 1.55 (0.23) 0.3133
8 Na 268 137.06 (5.82) 138.17 (10.12) 0.9906 8 123.28 (5.91) 122.14 (2.32) 0.9908
9 Platelets 476 79.21 (49.16) 63.39 (35.46) 0.0814 57 81.64 (68.08) 85.08 (18.66) 0.2811
10 WBC 476 4.86 (3.26) 5.99 (3.79) 0.03277 57 4.83 (5.16) 6.67 (3.56) 0.1378
Preoperative status, mean(sd)
11 MELD score 480 17.84 (8.90) 24.21 (9.36) 1.617E-05 58 16.69 (10.04) 29.75 (11.90) 0.021
12 Hepatitis, n(%) 0.1996 0.2852
Nil 83 71 (16.25) 12 (27.91) 19 16 (29.63) 3 (0.75)
Hepatitis B Virus (HBV) 277 253 (57.89) 24 (55.81) 22 21 (38.89) 1 (0.25)
Hepatitis C Virus (HCV) 96 90 (20.59) 6 (13.95) 16 16 (29.63) 0 (0)
Dual 24 23 (5.27) 1 (2.33) 11 1 (1.85) 0 (0)
13 HCC, n(%) 0.004467 0.2002
No 264 231 (52.86) 33 (76.74) 33 29 (53.70) 4 (1.0)
Yes 216 206 (47.14) 10 (23.26) 25 25 (46.30) 0 (0)
14 DX1, n(%) 0.1942
Virtual hepatitis 396 363 (83.26) 33 (76.74) 43 (79.63) 2 (0.50)
Alcoholic cirrhosis 35 32 (7.34) 3 (6.98) 6 (11.11) 1 (0.25)
Wilson’s disease 6 4 (0.92) 2 (4.65) 1 (1.85) 0 (0)
Primary Biliary cirrhosis 7 7 (1.61) 0 (0) 0 (0) 0 (0)
Biliary atesia 2 1 (0.23) 1 (2.33) 0 (0) 0 (0)
Fulminiant hepatitis 4 3 (0.69) 1 (2.33) 0 (0) 0 (0)
Secondary Biliary cirrhosis 1 1 (0.23) 0 (0) 0 (0) 0 (0)
Other malignancy 2 2 (0.46) 0 (0) 0 (0) 0 (0)
Others 26 23 (5.26) 3 (6.98) 4 (7.41) 1 (0.25)
Other details, mean(sd)
15 Graft-recipient weight ratio (GRWR, %) 387 1.01 (0.24) 1.03 (0.48) 0.4077 53 0.94 (0.2) 1.02 (0.23) 0.5004
16 Liver weight 413 633.15 (146.82) 520.61 (134.30) 4.163E05 50 644.68 (129.73) 620 (256.60) 0.8381
17 Types of liver transplant, n(%) 0.03325 0.7745
Living donor 414 382 (87.41) 32 (74.42) 54 51 (94.44) 3 (0.75)
Deceased donor 66 55 (12.59) 11 (25.58) 4 3 (5.56) 1 (0.25)