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. 2020 Mar 27;10:5569. doi: 10.1038/s41598-020-62501-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Therapeutic efficacy of DTX loaded liposomes in comparison with control groups (PBS, and Taxotere) in BABL/c models of 4T1 (upper panel) or TUBO (lower panel) mammary carcinoma. A: Body weight, B: Average tumor volume (mm³) in all treated groups and C: Survival of all groups was monitored. (n = 4 or 5, mean ± S.D). In 4T1 breast carcinoma tumor model, F1, F2, and F3 formulations significantly extended mouse survival compared to PBS (p < 0.01, p < 0.0, p < 0.05, respectively). Also, the overall survivals were significantly improved in mice treated with F1 liposomes compare to those received Taxotere (p < 0.05, log-rank).