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. 2020 Mar 27;10:5569. doi: 10.1038/s41598-020-62501-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Biodistribution of prepared nanoliposomes and free iodinated docetaxel formulated in ethanol in (D) different organs in BALB/c mice bearing 4T1 tumor at 12 and 24 h post injection of a single dose of 8 mg/kg docetaxel. (D). Panels (d1), (d2), (d3) and (d4) represent a ratio of radioiodinated docetaxel amount in tumor to radioiodinated docetaxel concentration in each organ (T/NT ratio) of each mouse at each time point. Panels (d5), (d6), (d7) and (d8) show a ratio of radioiodinated docetaxel amount in organs to radioiodinated docetaxel concentration in blood of each mouse at each time point. Data are expressed as mean percentage of injected dose per tissue ((%ID)/g) ± SD (n = 3). Statistically significant differences are shown as follows: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.000.1.