Table 1.
Size, ζ potential, DTX content and drug encapsulation efficiency of DTX loaded NLs.
| Formulation (Molar Ratio) | Z-Average (nm) | PDIa | ζ -potential (mV) | mg of DTX/ml | EEb (%) |
|---|---|---|---|---|---|
| Active loaded liposomes | |||||
| F1a: HSPC/mPEG2000-DSPE/Chol (85/5/10) | 109.8 ± 2.8 | 0.16 ± 0.00 | −10.8 ± 0.2 | 1.7 ± 0.2 | 53.12 ± 8.8 |
| F2a: HSPC/mPEG2000-DSPE/DPPG/Chol (85/5/5/10) | 115.1 ± 2.8 | 0.17 ± 0.03 | −12.4 ± 0.4 | 1.1 ± 0.1 | 34.3 ± 4.4 |
| F3a: HSPC/mPEG2000-DSPE/DSPG/Chol (85/5/5/10) | 116 ± 1.9 | 0.11 ± 0.00 | −13.8 ± 0.0 | 2.15 ± 0.2 | 67.18 ± 6.6 |
| Passive loaded liposomes | |||||
| F1p: HSPC/mPEG2000-DSPE/Chol (85/5/10) | 125.0 | 0.087 | −10.3 | 0.64 ± 0.2 | 20 ± 6.2 |
| F2p: HSPC/mPEG2000-DSPE/DPPG/Chol (85/5/5/10) | 139.0 | 0.156 | −10.9 | 0.57 ± 0.15 | 18 ± 4.7 |
| F3p: HSPC/mPEG2000-DSPE/DSPG/Chol (85/5/5/10) | 108.4 | 0.178 | −13.7 | 0.83 ± 0.3 | 26 ± 0.94 |
Each value depicts mean ± standard deviation (n = 3).
aPolydispersity index, bEncapsulation Efficacy.
Subscripts are abbreviations of active and passive loaded methods, respectively.