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. 2020 Mar 27;10:5627. doi: 10.1038/s41598-020-62344-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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hERG K⁺ current IC₅₀ concentrations. Graphical representation of hERG K⁺ current inhibition by the 12 test compounds: spread of individual log-IC₅₀ concentrations per compound and per site (compare Supplementary Tables S2–S4) with superimposed box-and-whiskers plot (median, 25/75 percentile, min/max values); the number of data points from automated platforms is indicated at the bottom of each column. Platforms used are color-coded as follows: p1, blue; p2, green; p3, orange; p4, black; and p5, black. Assays (s01–s19) were conducted at room temperature (open symbols) and at 35 °C (filled symbols). bep, bepridil; cpz, chlorpromazine; cis, cisapride; dil, diltiazem; dof, dofetilide; mex, mexiletine; ond, ondansetron; qui, quinidine; ran, ranolazine; sot, sotalol; ter, terfenadine; ver, verapamil.