Figure 2.

Risk of Major Coronary Events, Ischemic Stroke, and Intracerebral hemorrhage by quintiles of C-reactive protein (CRP) and fibrinogen. Models were adjusted for age, age² and sex (Base model) and additionally for income, occupation, education, SBP, BMI, diabetes, physical activity, standing height, smoking, alcohol, LDL-C and TG (Full model). These models were fitted separately for each of the 10 study areas for each quintile and estimates were meta-analyzed; in each quintile, study areas were excluded when models failed to converge (9 models out of 600 models). Cut-offs for CRP and Fibrinogen quintiles were based on their distribution in the combined case-control cohort (CRP: 0.37 mg/l, 0.70 mg/l, 1.28 mg/l, and 2.59 mg/l; Fibrinogen: 2.47 g/l, 2.81 g/l, 3.14 g/l, and 3.60 g/l). Error bars represent 95% floated confidence intervals (CI). The areas of the boxes are proportional to the inverse of the variance of the log ORs. OR, CRP, and fibrinogen are plotted on log scales.