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. 2020 Mar 27;10:5605. doi: 10.1038/s41598-020-62391-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Risk of Major Coronary Events, Ischemic Stroke, and Intracerebral hemorrhage per standard deviation (SD) of usual log-transformed high-sensitivity C-reactive protein (CRP) by pre-specified subgroups. Models were adjusted (where appropriate) for age, age² and sex (base model) and additionally for income, occupation, education, SBP, BMI, diabetes, physical activity, standing height, smoking, alcohol, LDL-C and TG. The models were fitted separately for each of the 10 study areas in each subgroup strata and estimates were meta-analyzed; in each subgroup strata, study areas were excluded when models failed to converge (62 models out of 750 models). Error bars represent 95% confidence intervals (CI). The sizes of the boxes are proportional to the inverse of the variance of the log ORs. The dotted line represents the overall adjusted OR. The open diamond represents the overall adjusted OR and its 95% CI. MET: metabolic equivalent of task; p-het: p-value for heterogeneity; p-trend: p-value for trend.