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. 2020 Mar 27;10:5555. doi: 10.1038/s41598-020-62272-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a,b) Immunofluorescence staining of (a) HIF-1α (green), the macrophage marker F4/80 (red) and DAPI nuclear stain (blue), and (b) lactate dehydrogenase (LDH, green), F4/80 (red) and DAPI (blue) in WAT of lean and obese mice. Colocalization is shown in the merged image (arrows). Scale bar = 100 µm. (c,d) Relative mRNA expression of (c) Hif1a and Hif2a, and the HIF target genes (d) Vegfa and Glut1 in ATM isolated from lean and obese mice (n = 3). (e) Levels of succinate in ATM of lean and obese mice (n = 6). (f) Relative mRNA levels of the glutamate transporter Slc3a2 in ATM from lean and obese (n = 3). Data is expressed as mean ± s.e.m. *p < 0.05.