Table 1.
The hubs (red), bottlenecks (green), and hub-bottlenecks (red-green) of migraine (BC refers to betweenness centrality).
| R | Name | Description | Degree | BC |
|---|---|---|---|---|
| 1 | ALB | Albumin | 121 | 0.131298 |
| 2 | INS | Insulin | 110 | 0.125716 |
| 3 | POMC | Proopiomelanocortin | 92 | 0.018258 |
| 4 | NPS | Neuropeptide S | 91 | 0.02901 |
| 5 | KNG1 | Kininogen 1 | 87 | 0.019268 |
| 6 | FOS | FBJ murine osteosarcoma viral oncogene homolog | 82 | 0.019946 |
| 7 | F2 | Coagulation factor II (thrombin) | 81 | 0.018713 |
| 8 | GNB3 | Guanine nucleotide binding protein (G protein), beta polypeptide 3 | 80 | 0.042513 |
| 9 | IL6 | Interleukin 6 (interferon, beta 2) | 78 | 0.020569 |
| 10 | TAC1 | Tachykinin, precursor 1 | 78 | 0.016064 |
| 11 | TNF | Tumor necrosis factor | 73 | 0.020693 |
| 12 | BDNF | Brain-derived neurotrophic factor | 70 | 0.024804 |
| 13 | EDN1 | Endothelin 1 | 70 | 0.018413 |
| 14 | EGF | Epidermal growth factor | 68 | 0.021209 |
| 15 | CRH | Corticotropin-releasing hormone | 66 | 0.006211 |
| 16 | NPY | Neuropeptide Y | 66 | 0.006144 |
| 17 | SST | Somatostatin | 64 | 0.010855 |
| 18 | NTS | Neurotensin | 62 | 0.02408 |
| 19 | HTR7 | 5-Hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled | 61 | 0.011028 |
| 20 | NOS3 | Nitric oxide synthase 3 (endothelial cell) | 60 | 0.019226 |
| 21 | CREB1 | cAMP responsive element binding protein 1 | 55 | 0.024585 |
| 22 | MMP9 | Matrix metallopeptidase 9 (Gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 49 | 0.027458 |
| 23 | TH | Tyrosine hydroxylase | 46 | 0.028666 |
| 24 | PRL | Prolactin | 45 | 0.02854 |
| 25 | CACNA1C | Calcium channel, voltage-dependent, L type, alpha 1C subunit | 43 | 0.038877 |
| 26 | WDTC1 | WD and tetratricopeptide repeats 1 | 41 | 0.026239 |
| 27 | ACLY | ATP citrate lyase | 36 | 0.052981 |
| 28 | CACNA1B | Calcium channel, voltage-dependent, N type, alpha 1B subunit | 36 | 0.028122 |
| 29 | CACNA1A | Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 33 | 0.027352 |
| 30 | NOTCH1 | Notch 1 | 30 | 0.023984 |
| 31 | ALDH7A1 | Aldehyde dehydrogenase 7 family, member A1 | 19 | 0.025062 |
| 32 | CLCN2 | Chloride channel, voltage-sensitive 2 | 13 | 0.027591 |
| 33 | GABRQ | γ-Aminobutyric Acid (GABA) A receptor, theta | 13 | 0.023171 |