Table 2.

Centralities of nodes of sub-network.

R	Name	Description	Degree	BC	R1
1	INS	Insulin	29	0.128	2
2	ALB	Albumin	27	0.061	1
3	FOS	FBJ murine osteosarcoma viral oncogene homolog	24	0.016	6
4	F2	Coagulation factor II (thrombin)	24	0.018	7
5	TAC1	Tachykinin, precursor 1	22	0.010	10
6	IL6	Interleukin 6 (interferon, beta 2)	22	0.021	9
7	SST	Somatostatin	22	0.010	17
8	TNF	Tumor necrosis factor	21	0.010	11
9	NPS	Neuropeptide S	21	0.007	4
10	EDN1	Endothelin 1	21	0.022	13
11	BDNF	Brain-derived neurotrophic factor	21	0.020	12
12	POMC	Proopiomelanocortin	21	0.007	3
13	CREB1	cAMP responsive element binding protein 1	21	0.020	21
14	NPY	Neuropeptide Y	20	0.006	16
15	KNG1	Kininogen 1	19	0.007	5
16	HTR7	5-Hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	19	0.010	19
17	EGF	Epidermal growth factor	19	0.008	14
18	PRL	Prolactin	18	0.062	24
19	NTS	Neurotensin	18	0.007	18
20	NOS3	Nitric oxide synthase 3 (endothelial cell)	18	0.020	20
21	CRH	Corticotropin releasing hormone	18	0.004	15
22	TH	Tyrosine hydroxylase	16	0.060	23
23	MMP9	Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	14	0.002	29
24	GNB3	Guanine nucleotide binding protein (G protein), beta polypeptide 3	14	0.019	8
25	WDTC1	WD and tetratricopeptide repeats 1	13	0.005	26
26	NOTCH1	Notch 1	11	0.005	30
27	CACNA1B	Calcium channel, voltage-dependent, N type, alpha 1B subunit	6	0.003	28
28	CACNA1A	Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	6	0.002	29
29	ALDH7A1	Aldehyde dehydrogenase 7 family, member A1	6	0.002	31
30	CACNA1C	Calcium channel, voltage-dependent, L type, alpha 1C subunit	5	0.001	25
31	ACLY	ATP citrate lyase	4	0.001	27
32	CLCN2	Chloride channel, voltage-sensitive 2	2	0.001	32
33	GABRQ	γ-Aminobutyric cid (GABA) A receptor, theta	2	0.001	33

BC refers to betweenness centrality, R1 indicates to row position in Table 1, the colored nodes are the hub-bottlenecks of migraine PPI network.