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. 2019 Jul 1;10(4):281–304. doi: 10.32598/bcn.9.10.250

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Copyright© 2019 Iranian Neuroscience Society

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 11. — Cumulative data that present the direct inhibition of the Bupropion (BP) on the VTA dopaminergic neurons

The effect of Microiontophoretic (MI) and Intracerebroventricular (ICV) application of the bupropion on the percentage of inhibited neurons, percentage of excited neurons, inhibition duration, excitation duration, and silent duration of the VTA dopaminergic neurons in different groups. Bupropion inhibited 97.5%, 70.1%, and 30.4% of VTA dopaminergic neurons at -500, -300, -150 nA, respectively without response at -50 nA. The percentages of inhibited neurons in ICV application of bupropion were 56%, 43%, 33%, 20%, 12%, and 3% at amounts of 1, 0.5, 0.1, 0.01, 0.001, and 0.0001 mol, respectively. The percentage of excited neurons in MI application of bupropion was 0% but they were 42%, 29%, 18%, 11%, 5%, and 2 % at 1, 0.5, 0.1, 0.01, 0.001, and 0.0001 mol in ICV application of bupropion, respectively. The Mean±SD duration periods of inhibition were 70±13, 45±11, 23±7 min at -500, -300, -150 nA, respectively without any inhibition at -50 nA. The Mean±SD duration periods of inhibition of neurons in the ICV application of bupropion were 56±11, 48±8, 24±4, 10±3, 5±1 min at the amounts of 1, 0.5, 0.1, 0.01, 0.001 mol, respectively without inhibition at 0.0001 mol. The mean excitation duration in MI application of bupropion was 0, but in the ICV application of bupropion, they were 32±10, 21±5, 11±4, 7±3, 2±2 min at amounts of 1, 0.5, 0.1, 0.01, 0.001 mol, respectively without excitation at 0.0001 mol. The MI application of bupropion made VTA dopaminergic neurons silent for 18±8, 12±4, 6±3 min at -500, -300, -150 nA, respectively without any silent neurons at -50 nA. The ICV application of bupropion made VTA dopaminergic neurons silent for 5±2, and 2±2 at 1 and 0.5 mol, respectively. However, there were no silent neurons at the remaining amounts.

The crosstab statistical test was used for statistical evaluation of descriptive data (percentage of inhibited and excited neurons). One-way repeated measures ANOVA and Tukey’s post hoc test were used for quantitating data evaluation. The data are presented as Mean±SD with significant levels of ^*** P<0.001; ^** P<0.01.