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. 2019 Jul 1;10(4):281–304. doi: 10.32598/bcn.9.10.250

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Copyright© 2019 Iranian Neuroscience Society

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Bar graph of the excitation response of the VTA dopaminergic neurons to the intracerebroventricular application of bupropion in different groups

The upper graph shows the mean of firing rate of the VTA dopaminergic neurons per different amount of bupropion (1, 0.5, 0.1, 0.01, 0.001, and 0.0001 mol, 5 μl/3min, at 11^th to 13^th min) and the lower graph shows the percentage of firing rate according to the pre-injection firing as 100%. Bupropion could excite the neurons dose-dependently. There were significant differences between the mean firing rates of the excitation periods of 1, 0.5, 0.1, and 0.01 mol of bupropion but the amounts of 0.001 and 0.0001 mol did not show any significant difference. One-way repeated measures ANOVA with Tukey’s post hoc test were used for statistical evaluation.

The data are represented as Man±SD with significant levels of ^*** P<0.001; ^** P<0.01; and ^* P<0.05; ICV-BP= Intracerebroventricular application of bupropion.