Figure 4.

Hypothetical schematic diagram shows the mechanism of whole-body mice gamma radiation induced-ER stress-mediated disruption of hippocampal homeostasis.

Radiation induces inhibition of Sostdc1 gene resulting in disruption of the WNT pathway, which might lead to ER stress of cells. Also, radiation downregulates Nectin3 resulting in hampered nectin-afadin complex and ultimately might be causing various neurodegenerative disorders. The onset of ER stress leads to the dissociation of BIP from the unfolded protein, ultimately leading to the subsequent activation of IRE1α, PERK, and AT6 pathway downstream in the ER lumen. Radiation inhibits WFS1 gene expression resulting in IRE1α-mediated apoptosis. IRE1α also activates MEK which leads to the phosphorylation of ERK½, which ultimately leads to apoptosis via phosphorylating DAPK.