Fig. 4.

Effects of TJ-41 on histopathologic changes in LPS-induced acute lung injury model. Representative pictures of lung tissue specimens from mice that received ordinary feed for 8 weeks (A–D) and those that received feed mixed with TJ-41 for 8 weeks (E–H). Histopathology was compared between the two groups at 0 h (A, E), 24 h (B, F), 72 h (C, G), and 96 h (D, H) after LPS challenge. No effect on the lung tissue findings was observed in mice that consumed feed mixed with TJ-41 for 8 weeks (E) compared with mice that consumed ordinary feed for 8 weeks (A). Alveolar thickening with the cellular infiltration of monocytes, neutrophils, and a few lymphocytes and neutrophil infiltration in the alveolar space are seen, particularly at 24 h after LPS challenge (B, F); however, these features were less severe in TJ-41-treated mice (F) [original × 100]