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. 2013 Sep 26;98(5):578–588. doi: 10.1007/s12185-013-1429-2

Table 1.

Patient characteristics according to age group

<1 year (n = 45) 1 to <2 years (n = 58) ≥2 years (n = 340) P value
n (%) n (%) n (%)
Sex
 Male 20 (44.4) 32 (55.1) 186 (54.7) 0.419
 Female 25 (55.5) 26 (44.8) 154 (45.2)
WBC at diagnosis (/μL)
 <10,000 8 (17.7) 20 (34.4) 128 (37.6) 0.051
 10,000–50,000 25 (55.5) 23 (39.6) 117 (34.4)
 >50,000 12 (26.6) 15 (25.8) 95 (27.9)
FAB classification
 M0 0 (0.0) 0 (0.0) 8 (2.3) <0.001
 M1 2 (4.4) 3 (5.1) 52 (15.2)
 M2 1 (2.2) 2 (3.4) 114 (33.5)
 M3 1 (2.2) 0 (0.0) 0 (0.0)
 M4 3 (6.6) 4 (6.8) 40 (11.7)
 M4Eo 1 (2.2) 5 (8.6) 9 (2.6)
 M5a 15 (33.3) 11 (18.9) 49 (14.4)
 M5b 4 (8.8) 4 (6.8) 11 (3.2)
 M6 0 (0.0) 5 (8.6) 5 (1.4)
 M7 14 (31.1) 21 (36.2) 13 (3.8)
 RAEBa 1 (2.2) 1 (1.7) 1 (0.2)
 RAEB-Ta 1 (2.2) 2 (3.4) 36 (10.5)
 ND 2 (4.4) 0 (0.0) 2 (0.5)
Cytogenetic characteristics
 t(8;21) 0 (0.0) 1 (1.7) 121 (35.5) <0.001
 inv(16) 1 (2.2) 6 (10.3) 25 (7.3)
 t(9;11) 8 (17.7) 9 (15.5) 22 (6.4)
 Other 11q23 abnormalities 11 (24.4) 4 (6.8) 15 (4.4)
 t(6;9) 0 (0.0) 0 (0.0) 3 (0.8)
 inv(3) 0 (0.0) 0 (0.0) 2 (0.5)
 t(1;22) 3 (6.6) 0 (0.0) 0 (0.0)
 t(7;12) 2 (4.4) 1 (1.7) 0 (0.0)
 Normal karyotype 6 (13.3) 6 (10.3) 68 (20.0)
 Others 13 (28.8) 31 (53.4) 82 (24.1)
 ND 1 (2.2) 0 (0.0) 2 (0.5)
FLT3-ITD status
 Positive 0 (0.0) 3 (5.1) 44 (12.9) 0.002
 Negative 44 (97.7) 55 (94.8) 296 (87.0)
 ND 1 (2.2) 0 (0.0) 0 (0.0)

WBC white blood cell count, FAB French–American–British, RAEB refractory anemia with excess blasts, RAEB-T refractory anemia with excess blasts in transformation, ND not detected, ITD internal tandem duplications

aAs the World Health Organization classification (3rd edition) was used, patients with <30 % bone marrow blasts were included in this study