. 2013 Sep 26;98(5):578–588. doi: 10.1007/s12185-013-1429-2

Table 2.

Initial treatment response according to age group and before/after the protocol amendments

Age group	<1 year				1 to <2 years	≥2 years	P value^b
	Before amendment	After amendment	P value^a	Total	1 to <2 years	≥2 years
	n = 28	n = 17	P value^a	n = 45	n = 58	n = 340
<5 % bone marrow blast after Ind-1	16 (57.1 %)	12 (70.5 %)	0.367	28 (62.2 %)	51 (87.9 %)	290 (85.2 %)	0.001
CR rate (after Ind-2)	19 (67.9 %)	14 (82.4 %)	0.488	33 (73.3 %)	49 (84.4 %)	299 (87.9 %)	0.036
Early death (≤42 days)	5 (17.9 %)	0 (0.0 %)	0.140	5 (11.1 %)	1 (1.7 %)	1 (0.2 %)	<0.001
Non-response	2 (7.1 %)	3 (17.6 %)	0.350	5 (11.1 %)	6 (10.3 %)	32 (9.4 %)	0.922
Other	2 (7.0 %)	0 (0.0 %)	0.519	2 (4.4 %)	2 (3.4 %)	8 (2.3 %)	0.670

Ind-1 induction course 1, CR complete remission, Ind-2 induction course 2

^aBefore versus after the protocol amendments

^bComparison among the three age groups