Table 3.
Characteristics of the six infants who died during the initial induction phase
| Patient | Characteristics at diagnosis | Cause of early death | Death (day+) | Infectious complications | Other complications |
||||
|---|---|---|---|---|---|---|---|---|---|
| Age (months) | Sex | WBC (/μL) | EMD | AML subtype (WHO-3/FAB) | |||||
| #1 | 7 | F | 58,000 | Yes | Acute monoblastic leukemia/M5a | Leukemia | 5 | No | No |
| #2 | 7 | F | 152,130 | Yes | AML with 11q23 abnormalities/M5a | ARDS | 62 | Sepsis | HPS |
| #3 | 4 | M | 7,200 | Yes | Acute monocytic leukemia/M5b | ARDS | 39 | FN | HPS |
| #4 | 7 | M | 7,900 | Yes | Acute monoblastic leukemia/M5a | ARDS | 22 | RSV infection | No |
| #5 | 7 | M | 7,840 | Yes | AML with 11q23 abnormalities/M4 | ARDS | 39 | RSV infection | HPS |
| #6 | 2 | F | 4,400 | No | AML with multilineage dysplasia/M1 | IP | 17 | Sepsis (S. aureus) | No |
WBC white blood cell count, EMD extramedullary disease, AML acute myeloid leukemia, WHO-3 World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues (3rd edition), FAB French–American–British, F female, M male, ARDS acute respiratory distress syndrome, IP interstitial pneumonia, FN febrile neutropenia, RSV respiratory syncytial virus, S. aureus Staphylococcus aureus, HPS hemophagocytic syndrome