Table I.

List of FDA-Approved Nucleic Acid Products

Drug name	Active ingredient	Year	Therapeutic agent	Indication	Route	Vehicle	Company
Vitravene	Fomivirsen	1998	Antisense oligonucleotide	Cytomegalovirus retinitis	Intravitreal injection	None	Isis Pharmaceuticals
Macugen	Pegatanib	2004	Aptamer	Age-related macular degeneration	Intravitreal injection	None	Eyetech Inc.
Kynamro	Mipomersen	2013	Antisense oligonucleotide	Homozygous familial hypercholesterolemia	Subcutaneous injection	None	Genzyme Corporation
Exondys 51	Eteplirsen	2016	Antisense oligonucleotide	Duchenne muscular dystrophy	Intravenous infusion	None	Sarepta Therapeutics
Spinraza	Nusinersen	2016	Antisense oligonucleotide	Spinal muscular atrophy	Intrathecal injection	None	Biogen Inc.
Defitelio	Defibrotide	2016	Oligonucleotide with profibrinolytic properties	Sinusoidal obstruction syndrome	Intravenous infusion	None	Jazz Pharmaceuticals, Inc.
Onpattro	Patisiran	2018	Small interference RNA	Polyneuropathy of hereditary transthyretin-mediated amyloidosis	Intravenous infusion	Lipid complex	Alnylam Pharma Inc.