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. 2018 Oct 18;19(8):3670–3680. doi: 10.1208/s12249-018-1183-0

Table III.

Summary of Nucleic Acid Drug Indicated for Pulmonary Diseases into Clinical Trials (Cited from http://www.clinicaltrials.gov/)

Drug Year Therapeutic agents Target Vehicle Route Condition Phase Status Sponsors Clinical trial ID
Custirsen (OGX-011) 2004–2010 ASO Clusterin None Intravenous injection NSCLC I II Completed Achieve Life Sciences NCT00138658
2012– III Ongoing NCT01630733
Imetelstat Sodium (GRN163L) 2007–2011 ASO Telomerase ASO-lipid conjugate Intravenous injection NSCLC I Completed Geron Corporation NCT00510445
2010–2016 II Completed NCT01137968
MRX34 2013–2016 miRNA miR-34a Liposome Intravenous injection NSCLC I Terminated Mirna Therapeutics, Inc. NCT01829971
TargomiRs 2015–2017 ASO miR-16 Nonliving bacterial minicells Intravenous injection NSCLC I Completed Asbestos Diseases Research Foundation NCT02369198
TPI-ASM8 2007–2007 ASO βc subunit of the IL-3, IL-5, GM-CSF receptors(TOP004) CCR3(TOP005) None Inhalation Asthma II Terminated Pharmaxis NCT00402948
2008–2008 II Completed NCT00550797
2009–2010 II Completed NCT00822861
2010–2012 II Completed NCT01158898
AIR645 2008–2009 ASO IL-4/IL-13 Receptor α chain None Inhalation Asthma I Completed Altair Therapeutics, Inc. NCT00658749
2009–2010 II Completed NCT00941577
SB010 2011–2012 ASO GATA-3 mRNA None Inhalation Asthma I Completed Sterna Biologicals GmbH & Co. KG NCT01470911
2012–2012 I Completed NCT01554319
2012–2014 I Completed NCT01577953
2012–2015 II Completed NCT01743768
TPI 1100 2009–2010 ASO PDE4/PDE7 None Inhalation COPD I Withdrawn Pharmaxis NCT00914433
QR-010 2015–2016 ASO CFTR mRNA None Inhalation intranasal route Cystic fibrosis I Completed ProQR Therapeutics NCT02564354
2015– I b Ongoing NCT02532764
ALN-RSV01 2007 July–November siRNA RSV-N gene None Inhalation or intranasal route Respiratory syncytial virus infections II Completed Alnylam Pharmaceuticals NCT00496821
2008–2009 II Completed NCT00658086
2010–2012 II Completed NCT01065935

Abbreviations: ASO antisense oligonucleotide, NSCLC non-small cell lung cancer, siRNA small interference RNA, COPD chronic obstructive pulmonary disease