Table 1.

Medical complications associated with vascularized composite tissue allotransplantation

Medical complications associated with VCA
Preoperative comorbid conditions adversely affecting outcomes	Depression Post-traumatic stress disorder Substance abuse Lack of social support Lack of continuous medical support HIV positive CMV mismatch with donor Need for multiple VCA
Peri-, intra-operative complications	High transfusion requirement Hemodynamic instability Graft thrombosis Nosocomial infections Respiratory distress, ARDS Acute and chronic renal failure Acute rejection Metabolic disorders Graft edema Rhabdomyolysis
Rejection	Acute rejection Chronic rejection Development of donor specific antibodies
Infection	Nosocomial infections Pseudomonal graft infections Sepsis Hardware infections Osteomyelitis Pneumonia (aspiration, ventilator associated) Pulmonary aspergilloma Candida surgical site infections Tinea/noninvasive cutaneous fungal infections Viral infections (CMV, HSV, VZV, HPV)
Malignancy	Lymphoma Reoccurrence Cutaneous malignancies Hepatocellular carcinoma Lung cancer
Renal and metabolic	Acute and chronic renal failure Diabetes Metabolic syndrome Osteoporosis SIADH
Graft dysfunction	Poor outcome, non-functional graft Graft failure Graft loss