Table 2.
Clinical features
| Characteristics | Definite PCPa (n = 7) | Probable PCP (n = 4) | Possible PCP (n = 5) | Other diagnosisd (n = 19) | p-Value |
|---|---|---|---|---|---|
| Age, years | 66 (47–69) | 66 (52–75) | 65 (60–67) | 49 (42–66) | 0.34 |
| Male sex | 3 (43 %) | 1 (25 %) | 2 (40 %) | 9 (47 %) | 0.874 |
| Underlying disease | |||||
| Hematological malignancy | 4 (57 %) | 4 (100 %) | 4 (80 %) | 13 (68 %) | 0.46 |
| Solid malignancy | 1 (14 %) | 0 (0 %) | 0 (0 %) | 1 (5 %) | 0.68 |
| Organ transplantation | 0 (0 %) | 0 (0 %) | 0 (0 %) | 4 (21 %) | 0.28 |
| HIVb infection | 2 (29 %) | 0 (0 %) | 0 (0 %) | 1 (5 %) | 0.2 |
| Inflammatory disease | 0 (0 %) | 0 (0 %) | 1 (20 %) | 0 (0 %) | 0.1 |
| Corticosteroids | 2 (29 %) | 1 (25 %) | 2 (40 %) | 4 (21 %) | 0.85 |
| Anti-tumor chemotherapy | 2 (29 %) | 2 (50 %) | 2 (40 %) | 11 (58 %) | 0.59 |
| Immunosuppressive agents other than corticosteroids or chemotherapy | 1 (14 %) | 1 (25 %) | 2 (40 %) | 3 (16 %) | 0.64 |
| PCP prophylaxis | 0 (0 %) | 0 (0 %) | 0 (0 %) | 1 (5 %) | 0.83 |
| Hypoxia | 7 (100 %) | 3 (75 %) | 5 (100 %) | 11 (58 %) | 0.19 |
| Stay in ICUc | 2 (29 %) | 2 (50 %) | 0 (0 %) | 5 (26 %) | 0.39 |
| Anti-PCP treatment | 7 (100 %) | 4 (100 %) | 5 (100 %) | 12 (63 %) | 0.06 |
| Mechanical ventilation | 2 (29 %) | 0 (0 %) | 0 (0 %) | 5 (26 %) | 0.38 |
| Laboratory findings | |||||
| Leucocytes, /mm3 | 2,100 (1,700–9,825) | 7,150 (6,600–8 750) | 9,100 (750–10 025) | 3,700 (2,325–5,900) | 0.4 |
| Neutrophils, /mm3 | 1,400 (1,125–5,650) | 5,850 (5,200–7,250) | 4,650 (1,800–8,150) | 2,600 (2,200–5,525) | 0.28 |
| Lymphocytes, /mm3 | 400 (225–600) | 950 (450–1,300) | 400 (350–2,150) | 500 (225–800) | 0.77 |
| C-reactive protein, mg/dl | 11.8 (2.6–17.9) | 10.5 (4.95–14.1) | 10.7 (4.5–20) | 9.3 (3.9–6.2) | 0.99 |
| Creatinine, mg/dl | 0.8 (0.61–1) | 0.84 (0.74–1.37) | 0.71 (0.6–1.3) | 0.97 (0.63–1.1) | 0.91 |
| Death | 0 (0 %) | 0 (0 %) | 0 (0 %) | 3 (16 %) | 0.43 |
Data are presented as n (%) or median (interquartile range)
a Pneumocystis pneumonia
bHuman immunodeficiency virus
cIntensive care unit
dThe “other diagnoses” group included bacterial pneumonia (n = 2), atypical pneumonia (n = 2), influenza virus pneumonia (n = 1), acute respiratory distress syndrome (ARDS) due to sepsis (n = 1), candidemia (n = 1), bronchiolitis obliterans organizing pneumonia (n = 1), drug-induced pneumonia (n = 1), bronchial hamartoma (n = 1), multifactorial pulmonary fibrosis (n = 1), allergic bronchopulmonary aspergillosis (n = 1), pulmonary lymphoma (n = 2), and undetermined (n = 5)