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. 2017 Oct 9;195(6):749–757. doi: 10.1007/s00408-017-0058-6

Table 3.

Genotypes distribution and alleles frequencies of IL8 polymorphisms according to atopic status

Atopy IL-8 SNPs Genotypes Alleles Population χ 2 P OR (95%CI)
Patients N (%) Controls N (%)
Atopic asthma
rs4073 10.35 0.005
AA 9 (7.69) 31 (18.23) 1.00a
AT 47 (40.17) 78 (45.88) 2.45 0.11 2.08 (0.85–5.17)
TT 61 (52.13) 61 (35.88) 8.20 0.004 3.44 (1.42–8.55)
A 65 (27.77) 140 (41.17) 1.00b
T 169 (72.22) 200 (58.82) 10.26 0.001 1.82 (1.25–2.65)
rs2227306 7.27 0.02
TT 8 (6.84) 27 (15.88) 1.00a
CT 43 (36.75) 69 (40.60) 2.20 0.13 2.10 (0.82–5.56)
CC 66 (56.41) 74 (43.52) 5.81 0.015 3.01 (1.20–7.78)
T 59 (62.6) 123 (36.18) 1.00b
C 175 (37.4) 217 (63.82) 7.19 0.007 1.68 (1.14–2.47)
Non-atopic asthma
rs4073 4.79 0.09
AA 4 (7.54) 31 (18.23) 1.00a
AT 23 (43.39) 78 (45.88) 1.45 0.22 2.29 (0.67–8.53)
TT 26 (49.05) 61 (35.88) 3.64 0.05 3.30 (0.97–12.30)
A 31 (29.24) 140 (41.17) 1.00b
T 75 (70.75) 200 (58.82) 4.37 0.03 1.69 (1.03–2.79)
rs2227306 4.93 0.08
TT 4 (7.55) 27 (15.88) 1.00a
CT 30 (56.60) 69 (40.60) 2.85 0.09 2.93 (0.87–10.88)
CC 19 (35.85) 74 (43.52) 0.44 0.50 1.73 (0.49–6.65)
T 38 (35.85) 123 (36.18) 1.00a
C 68 (64.15) 217 (63.82) 0.00 0.95 1.01 (0.63–1.64)

Bold number indicates significant association

OR odds ratio, n number

aReference