. 2017 Oct 9;195(6):749–757. doi: 10.1007/s00408-017-0058-6

Table 3.

Genotypes distribution and alleles frequencies of IL8 polymorphisms according to atopic status

Atopy	IL-8 SNPs	Genotypes	Alleles	Population		χ ²	P	OR (95%CI)
Atopy	IL-8 SNPs	Genotypes	Alleles	Patients N (%)	Controls N (%)	χ ²	P	OR (95%CI)
Atopic asthma
	rs4073					10.35	0.005
		AA		9 (7.69)	31 (18.23)	1.00^a
		AT		47 (40.17)	78 (45.88)	2.45	0.11	2.08 (0.85–5.17)
		TT		61 (52.13)	61 (35.88)	8.20	0.004	3.44 (1.42–8.55)
			A	65 (27.77)	140 (41.17)	1.00^b
			T	169 (72.22)	200 (58.82)	10.26	0.001	1.82 (1.25–2.65)
	rs2227306					7.27	0.02
		TT		8 (6.84)	27 (15.88)	1.00^a
		CT		43 (36.75)	69 (40.60)	2.20	0.13	2.10 (0.82–5.56)
		CC		66 (56.41)	74 (43.52)	5.81	0.015	3.01 (1.20–7.78)
			T	59 (62.6)	123 (36.18)	1.00^b
			C	175 (37.4)	217 (63.82)	7.19	0.007	1.68 (1.14–2.47)
Non-atopic asthma
	rs4073					4.79	0.09
		AA		4 (7.54)	31 (18.23)	1.00^a
		AT		23 (43.39)	78 (45.88)	1.45	0.22	2.29 (0.67–8.53)
		TT		26 (49.05)	61 (35.88)	3.64	0.05	3.30 (0.97–12.30)
			A	31 (29.24)	140 (41.17)	1.00^b
			T	75 (70.75)	200 (58.82)	4.37	0.03	1.69 (1.03–2.79)
	rs2227306					4.93	0.08
		TT		4 (7.55)	27 (15.88)	1.00^a
		CT		30 (56.60)	69 (40.60)	2.85	0.09	2.93 (0.87–10.88)
		CC		19 (35.85)	74 (43.52)	0.44	0.50	1.73 (0.49–6.65)
			T	38 (35.85)	123 (36.18)	1.00^a
			C	68 (64.15)	217 (63.82)	0.00	0.95	1.01 (0.63–1.64)

Bold number indicates significant association

OR odds ratio, n number

^aReference