Fig. 7.

Real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis of fibrosis-related indicators. Note: Including transforming growth factor-β1 (TGF-β1), Collagen, type I, alpha 2 (COL1α2) and Collagen, type IV, alpha 5 (COL4α5) mRNA expression. Compared to the Sham group, the mRNA expression levels of TGF-β1, Col I and Col IV were also significantly higher in the AF-Control and Ad-EGFP dogs, while they were significantly lower in the Ad-ACE2 group in comparisons with latter two groups. *p < 0.001 versus sham; ^# p < 0.001 versus sham; ^♂ p < 0.01 versus AF-Control and Ad-EGFP, n = 7