Table 5.

Semi-quantitative immunohistochemical analysis of the expression of Ang II and Ang-(1–7)

Optical density mean	Sham	AF-Control	Ad-EGFP	Ad-ACE2	p*	p #	p ♂
Ang II	52.6 ± 13.9	78.1 ± 23.7	84.6 ± 12.3	27.0 ± 7.3	<0.01	<0.001	<0.001
Ang-(1–7)	32.2 ± 10.2	19.6 ± 7.4	17.6 ± 5.9	43.6 ± 4.8	0.004	<0.001	< 0.001

* Sham vs. AF-control; ^# Sham vs. Ad-EGFP; ^♂ Ad-ACE2 vs. Ad-EGFP (or AF-control); Ang II, Sham vs. Ad-ACE2, p < 0.001; Ang-(1–7), Sham vs. Ad-ACE2, p < 0.01, n = 7