Table 1.
Characteristics in ABO-I or ABO-C recipients: phenotypic and functional characteristics of CD8+ T cell subsets before LDLT in three groups of ABO-I or ABO-C recipients
| Characteristic | Group I | Group II | Group III | ||||||
|---|---|---|---|---|---|---|---|---|---|
| ABO-I | ABO-C | P* | ABO-I | ABO-C | P | ABO-I | ABO-I | P | |
| n | 7 | 31 | 4 | 33 | 15 | 28 | |||
| Age (y) | 46 ± 12 | 47 ± 11 | 0.8591 | 56 ± 8 | 53 ± 9 | 0.5536 | 53 ± 11 | 53 ± 12 | 0.9509 |
| % Naïve T cells | 58.34 ± 14.38 | 53.44 ± 10.42 | 0.3010 | 9.99 ± 4.26 | 20.80 ± 11.99 | 0.0855 | 21.38 ± 10.97 | 21.22 ± 10.52 | 0.9641 |
| % CM T cells | 6.08 ± 3.30 | 7.56 ± 4.19 | 0.3885 | 9.82 ± 5.20 | 11.88 ± 6.04 | 0.5194 | 3.48 ± 2.43 | 5.88 ± 3.43 | 0.0207 |
| % EM T cells | 5.39 ± 3.07 | 7.01 ± 5.53 | 0.4610 | 25.61 ± 15.47 | 20.24 ± 7.21 | 0.2273 | 8.82 ± 4.49 | 7.13 ± 4.79 | 0.2660 |
| % Effector T cells | 17.51 ± 7.76 | 18.49 ± 11.98 | 0.7869 | 30.14 ± 12.86 | 24.25 ± 11.66 | 0.3509 | 47.19 ± 12.86 | 48.36 ± 12.77 | 0.7765 |
| % CD27−CD28− subsets | 13.04 ± 9.59 | 16.78 ± 8.90 | 0.4106 | 14.09 | 42.84 ± 17.40 | 48.65 ± 18.88 | 40.83 ± 18.34 | 0.3614 | |
| % IFN-γ | 13.10 ± 8.58 | 9.09 ± 3.76 | 0.1956 | 17.45 | 13.21 ± 8.00 | 25.44 ± 16.35 | 20.29 ± 16.36 | 0.6318 | |
| % TNF-α | 11.82 ± 9.62 | 7.98 ± 2.72 | 0.2711 | 10.62 | 13.33 ± 7.73 | 25.86 ± 13.07 | 21.08 ± 19.53 | 0.6981 | |
| % IL-12Rβ1 | 41.65 ± 15.25 | 45.72 ± 11.65 | 0.6280 | 74.85 ± 0.83 | 71.02 ± 13.53 | 0.7121 | 71.53 ± 9.61 | 73.05 ± 13.08 | 0.8303 |
| % Perforin | 19.36 ± 10.43 | 13.93 ± 7.49 | 0.2109 | 14.82 ± 0.21 | 23.66 ± 11.82 | 0.3414 | 35.88 ± 17.24 | 26.79 ± 8.16 | 0.1713 |
LDLT, living donor liver transplantation; ABO-I, ABO-incompatible; ABO-C, ABO-identical and compatible; CM T cells, central/memory T cell subsets, CD45RO+CCR7+; EM T cells, effector/memory T cell subsets, CD45RO+CCR7–; IFN-γ, interferon-gamma; TNF-α, tumor necrosis factor alpha; IL-12Rβ1, interleukin-12 receptor beta1
Values expressed are mean ± SD
* P values based on ANOVA