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Negative regulation of SOCS-1 on smoke-induced ATP and K+ efflux. Ad-GFP or Ad-SOCS-1-treated mice were exposed to smoke for 15 min and allowed to rest for 1 day. Isolated alveolar macrophages were analyzed for a ATP release and b intracellular and c extracellular K+ levels.(P < 0.01 vs. the Ad-GFP group).
