Table 2.
Clinicopathologic characteristics and outcome of 110 Asian patients with T-large granular lymphocyte leukemia
| Parameters | Patients | ||
|---|---|---|---|
| Reported Asiana | Current series | p value | |
| Sex | |||
| Male | 43 | 14 | |
| Female | 45 | 8 | 0.215 |
| Age (mean ± standard error of the mean, years) | 58.3 ± 1.7 | 52.3 ± 3.2 | 0.118 |
| Hemoglobin | |||
| Mean ± standard error of the mean (g/dL) | 9.0 ± 0.4 | 8.1 ± 0.7 | 0.236 |
| Low (<10 g/dL) | 49 | 17 | 0.064 |
| Neutrophil count | |||
| Mean ± standard error of the mean (×109/L) | 3.4 ± 0.3 | 4.8 ± 1.0 | 0.179 |
| Low (<1.5 × 109/L) | 25 | 8 | 0.466 |
| Large granular lymphocyte count | |||
| Mean ± standard error of the mean (×109/L) | 8.0 ± 0.8 | 3.4 ± 0.7 | <0.001 |
| High (>2 × 109/L) | 77 | 14 | 0.008 |
| Platelet count | |||
| Mean ± standard error of the mean (×109/L) | 265 ± 14 | 204 ± 28 | 0.436 |
| Low (<150 × 109/L) | 13 | 5 | 0.367 |
| Hepatomegaly | |||
| Present | 4 | 5 | |
| Absent | 84 | 17 | 0.005 |
| Splenomegaly | |||
| Present | 8 | 8 | |
| Absent | 80 | 14 | 0.001 |
| Pure red cell aplasia | |||
| Present | 37 | 15 | |
| Absent | 51 | 7 | 0.028 |
| Rheumatoid arthritis | |||
| Present | 4 | 0 | |
| Absent | 84 | 22 | 0.308 |
| Autoimmune phenomena | |||
| Autoimmune hemolysis | 1 | 0 | |
| Autoimmune thyroiditis | 1 | 0 | |
| Bechet disease | 1 | 0 | |
| Aplastic anemia | 1 | 0 | |
| Immune thrombocytopenia purpura | 0 | 1 | |
| Other associated conditions | |||
| Infection as presentation | 3 | 0 | |
| Acute myeloid leukemia | 1 | 0 | |
| Autologous hematopoietic stem cell transplantation | 1 | 0 | |
| Renal allografting | 1 | 0 | |
| Parvovirus B19 infection | 1 | 0 | |
| Allogeneic hematopoietic stem cell transplantation | 0 | 1 | |
| T-cell receptor gene rearrangement | |||
| Clonal rearrangement | 70 | 20 | |
| Non-clonal rearrangement | 6 | 2 | |
| Not reported | 11 | ||
| Treatment outcome | |||
| Cyclophosphamide-induced remission | 15/20 | 0/6 | |
| Cyclosporine-induced remission | 4/5 | 4/14 | |
| Fludarabine-induced remission | 0 | 8/13 | |
| Remission induced by other agents | 0 | 0 | |
| Spontaneous remission | 4 | 0 | |
aThe results do not always add up to the total number of patients because some data may be missing from the articles reviewed