. 2010 Jan 19;89(4):331–339. doi: 10.1007/s00277-009-0895-3

Table 3.

Comparison of clinicopathologic features and treatment outcome of 110 Asian and 272 Western patients with T-large granular lymphocyte leukemia

Parameters	Asian patients^a	Western patients^a	p values
Number	110	272
Gender
Male	57	125	0.313
Female	53	146	0.313
Anemia (hemoglobin, ≤10 g/dL)
Present	66	113	0.025
Absent	44	127	0.025
Neutropenia (ANC ≤1.5 × 10⁹/L)
Present	33	146	<0.001
Absent	77	89	<0.001
LGL lymphocytosis (≥2 × 10⁹/L)
Present	91	133	0.732
Absent	19	31	0.732
Thrombocytopenia (≤150 × 10⁹/L)
Present	18	47	0.218
Absent	92	165	0.218
Hepatomegaly
Present	9	35	0.109
Absent	101	211	0.109
Splenomegaly
Present	16	99	<0.001
Absent	94	147	<0.001
Pure red cell aplasia
Present	52	6	<0.001
Absent	58	137	<0.001
Rheumatoid arthritis
Present	4	73	<0.001
Absent	106	199	<0.001
Other autoimmune phenomena
Present	5	5	0.133
Absent	105	267	0.133
Recurrent infections
Present	3	81	<0.001
Absent	107	191	<0.001
Treatment outcome
Cyclophosphamide-induced remission	15/26	4/23
Cyclosporine-induced remission	8/19	11/30
Fludarabine-induced remission	8/13	0
Remission induced by other agents	0	1/10
Spontaneous remission	4	1

^aThe results do not always add up to the total number of patients, because some data may be missing from the articles reviewed