Table 4.
Demographic and clinical characteristics of enrolled patients in relation to genotyping of rs1800796 of IL-6
| Characteristics | GG (n = 155) | GC and CC (n = 43) | p |
|---|---|---|---|
| Male gender (n, %) | 96 (61.9) | 21 (48.9) | 0.039 |
| Age (years, mean ± SD) | 74.5 ± 13.5 | 76.3 ± 10.7 | 0.497 |
| White blood cells (/mm³, mean ± SD) | 17,989.3 ± 14,121.3 | 15,443.5 ± 7,356.9 | 0.274 |
| APACHE II (mean ± SD) | 21.7 ± 6.7 | 20.5 ± 6.7 | 0.434 |
| SOFA score (mean ± SD) | 7.73 ± 3.84 | 7.48 ± 4.44 | 0.791 |
| Severe sepsis/shock (n, %) | 111 (71.6) | 25 (58.1) | 0.138 |
| Multiple organ dysfunction on day 1 (n, %) | 70 (45.2) | 13 (30.2) | 0.084 |
| Underlying infection (n, %) | |||
| Acute pyelonephritis | 64 (41.3) | 20 (46.5) | |
| Community-acquired pneumonia | 29 (18.7) | 12 (27.9) | |
| Intraabdominal abscess | 14 (9.0) | 2 (4.7) | |
| Primary bacteremia | 25 (16.1) | 3 (7.0) | 0.702 |
| Ventilator-associated pneumonia | 9 (5.8) | 3 (7.0) | |
| Hospital-acquired pneumonia | 8 (5.2) | 2 (4.6) | |
| Catheter-related infection | 6 (3.9) | 1 (2.3) | |
| Isolated microorganisms from blood (n, %) | |||
| Escherichia coli | 21 (13.5) | 5 (11.6) | |
| Acinetobacter baumannii | 8 (5.2) | 0 (0) | |
| Staphylococcus aureus | 7 (4.5) | 3 (6.9) | 0.803 |
| Klebsiella pneumoniae | 6 (3.9) | 1 (2.3) | |
| Pseudomonas aeruginosa | 5 (3.2) | 0 (0) | |
| Other | 8 (5.2) | 1 (2.3) | |
| Isolated microorganisms from urine (n, %) | |||
| Escherichia coli | 25 (16.1) | 11 (25.6) | |
| Klebsiella pneumoniae | 10 (6.5) | 2 (4.7) | |
| Pseudomonas aeruginosa | 5 (3.2) | 1 (2.3) | 0.633 |
| Proteus mirabilis | 5 (3.2) | 2 (4.7) | |
| Other | 3 (1.9) | 0 (0.0) | |
| Underlying conditions (n, %) | |||
| End-stage chronic renal disease | 50 (32.5) | 12 (27.9) | 0.711 |
| Type 2 diabetes mellitus | 67 (43.2) | 22 (51.2) | 0.389 |
| Chronic heart failure | 63 (40.6) | 16 (37.2) | 0.728 |
| Chronic obstructive pulmonary disorder | 28 (18.1) | 6 (14.0) | 0.650 |
| Solid tumor malignancy | 20 (12.9) | 9 (20.9) | 0.223 |
| All-cause 28-day mortality (n, %) | 62 (40.0) | 18 (41.9) | 0.862 |
| Death due to infection | 22 (14.6) | 17 (39.5) | |
| Death due to non-infectious related cardiovascular events | 40 (25.8) | 1 (2.4) | 0.031 |