Table 1.
Adult T-cell leukemia/lymphoma (ATLL): classifications and characteristics
| Type, n (%) | Smoldering, 45 (5.5) | Chronic, 152 (18.6) | Lymphoma, 156 (19.1) | Acute, 465 (56.8) |
|---|---|---|---|---|
| Abnormal T cells | >5 % in PB, normal lymphocyte level | >5 % in PB, lymphocytosis | <1 % in PB, no lymphocytosis | Both leukemia and tumor |
| Labs | No hypercalcemia, LDH >1.5× nl | No hyperCa, LDH >2× nl | Some hyperCa, LDH >2× nl | 50 % hyperCa, LDH >3× nl |
| LAD | None | Present | Present | Present |
| Organs involved | Rare, skin and lungs | Liver, spleen, skin, lung | +/− | Present |
| MST | Not reached at end of study | 24.3 months | 10.2 months | 6.2 months |
| Two-year survival | 77.7 % | 52.4 % | 21.3 % | 16.7 % |
| Four-year survival | 62.8 % | 26.9 % | 5.7 % | 5 % |