Table 2.
Type II cytokine receptors, ligands, and associated Janus kinase (JAK) and signal transduction and activator of transcription (STAT) molecules
| Ligand/cytokine | Associated JAK | Associated STAT |
|---|---|---|
| IFNα/β | JAK1, TYK2 | STAT1, STAT2, STAT4, sometimes STAT3 |
| IFNγ | JAK1, TYK2 | STAT1 |
| IL-10 | JAK1, JAK2, TYK2 | STAT135 |
| IL-19 | JAK1, JAK2, TYK2 | STAT3 |
| IL-20 | JAK1, JAK2, TYK2 | STAT3 |
| IL-22 | JAK1, JAK2, TYK2 | STAT1, STAT3, STAT5 |
| IL-24 | JAK1 | STAT3 |
| IL- 28 | JAK1, TYK2 | STAT1, STAT2, STAT3, STAT4, STAT5 |
| IL-29 | JAK1, TYK2 | STAT1, STAT2, STAT3, STAT4, STAT5 |
IFN interferon, IL interleukin, TYK tyrosine kinase