Fig. 1.

LPS-induced autophagy inhibition is accompanied with Thy-1 downregulation and integrin β3 upregulation in LPS-induced pulmonary fibrosis. The severity of pulmonary fibrosis was determined by hematoxylin-eosin (H&E) staining; collagen deposition was revealed by MASSON staining (magnification, ×200) (a). The expression of α-SMA in lung tissues was also measured by Western blot (b). Collagen deposition was measured by hydroxyproline content and collagen level assessments (c). Representative Western blot images showing expression of Thy-1, integrin β3, LC3 and P62 in the lung tissue (d). Values are mean ± SD (n = 6). *p < 0.05 vs control group; **P < 0.01 vs control group