Table 2.

Clinical characteristics of pediatric Zika virus infections

Author	Number of cases	Median age (range), years	Female gender, N (%)	Symptoms, N (%)				Neurological complications	Hospitalized
				Fever	Rash	Conjunctivitis	Arthralgia
Karwowski MP et al.a	10	13.5 (3–16)	4 (40)	10 (100)	0 (0)	2 (20)	3 (30)	ID	ID
Goodman AB, et al.b,c	158	14 (0.1–17)	88 (56)	87 (55)	129 (82)	45 (29)	44 (28)	0 (0)	2 (1)d
Li J, et al.e	14	11 (0.5–16)	7 (50)	9 (64)	14 (100)f	4 (29)	2 (14)g	0 (0)	14 (100)h

ID incomplete data, see text

^aThis report describes a total of 10 pediatric cases reported in 6 publications [39–44]. Other reported symptoms include malaise (N = 5), headache (N = 5), dizziness (N = 3), myalgia (N = 4), and sore throat (N = 2)

^bAll cases were reported from the continental US, and they were travel-associated. Children living in Puerto Rico and other US territories were excluded

^c70% had ≥2 of the four signs and symptoms, and 54% had fever and rash, 33% had ≥ three of the primary signs and symptoms. Other reported symptoms include headache, myalgia, vomiting, diarrhea, retro-orbital pain, chills, and throat

^dOne child (aged 4 years) required inpatient care for 3 days because of fever, cough, and poor oral intake, and another child (aged 1 year) was hospitalized for 1 day

^eZIKV infections were locally acquired

^fAt presentation only 50% had rash; the maximum duration of rash among patients with ZIKV infection only (N = 13) was 4 days. Other relevant symptoms reported included headache and myalgia reported by three patients, respectively

^gOne of two had a coinfection with dengue

^hAll had been admitted only because of temporary quarantine mandate in Singapore between 27 August and 5 September 2016