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. 2020 Mar 18;26:e920557-1–e920557-13. doi: 10.12659/MSM.920557

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© Med Sci Monit, 2020

This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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Inhibition of microRNA-375 (miR-375) reduced contractile dysfunction of doxorubicin-treated adult murine cardiomyocytes (AMCs) in vitro. (A) The resting length and peak shortening of adult murine cardiomyocytes (AMCs) (n=6). (B) The maximal velocity of shortening and re-lengthening (±dL/dt) (n=6). (C) Time to peak shortening (TPS) and time to 90% re-lengthening (TR90) in AMCs that analyzed by the IonOptix SoftEdge software (n=6). (D) Resting fura-2-acetoxymethyl ester (Fura-2AM) fluorescence intensity (FFI) in AMCs (n=6). (E) The alteration of FFI (ΔFFI) in AMCs (n=6). (F) Intracellular Ca²⁺ decay rate (single exponential and biexponential) in AMCs (n=8). (G) Ca²⁺-ATPase (SERCA2α) activity in AMCs (n=6). All data are presented as the mean±standard deviation (SD). * P<0.05 when compared with the matched group.