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. 2020 Mar 18;26:e920557-1–e920557-13. doi: 10.12659/MSM.920557

Figure 7.

Figure 7

Inhibition of microRNA-375 (miR-375) had protective effects on doxorubicin-induced cardiac toxicity in mice in vivo. (A–E) Statistical results of the left ventricular fractional shortening (LVFS), left ventricular end-systolic dimension (LVESD), left ventricular stroke volume (LVSV), and left ventricular end-diastolic pressure (LVEDP) and the maximal velocity of shortening and re-lengthening (±dL/dt) in mice with consecutive injections of doxorubicin (n=8). (F) Serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and creatine kinase (CK) in mice with doxorubicin-induced myocardial toxicity (n=6). (G) The survival rate in mice with repeated injections of low-dose doxorubicin (n=20). All data are presented as the mean±standard deviation (SD). * P<0.05 when compared with the matched group.