TABLE 2.
HepQuant SHUNT parameters in the cohort of 14 patients with Fontan-associated liver disease compared to healthy controls
| HepQuant SHUNT parameter | Control SD (±) |
Fontan SD (±) |
||
|---|---|---|---|---|
| Mean | SD (±) | Mean | SD (±) | |
| Disease severity index (DSI)* | 9.2 | 3.4 | 17.5 | 4.7 |
| Portal-systemic shunt fraction (SHUNT) (%)** | 24.1 | 7.5 | 36.1 | 17.7 |
| Systemic hepatic filtration rate (ml/min/kg) | 6.5 | 1.5 | 4.7 | 1.5 |
| Portal hepatic filtration rate (ml/min/kg) | 29.1 | 9.0 | 15.2 | 7.5 |
Normal range for disease severity index (DSI) is <15.
Normal range for portal-systemic shunt fraction (SHUNT) is <30%.