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. 2020 Mar 27;12:33. doi: 10.1186/s13195-020-00589-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Hazard ratio for association of combined medication use with AD diagnosis after TBI. a Patients taking two combined medications were compared to those taking both statins and metformin using the Cox model. The ACEI and statin group showed the most stable reduction in hazard ratio for developing dementia with possible AD. b Hazard ratio of same group of patients was analyzed using the Cox model with a propensity score adjusted for demographic factors. c Patients taking two combined medications were compared to those taking no medication using the Cox regression model. d Hazard ratio from the same group of patients was analyzed using the Cox regression model with a propensity score adjusted for demographic factors