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. 2020 Mar 27;12:33. doi: 10.1186/s13195-020-00589-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Kaplan-Meier adjusted survival plot reveals rank order of different combinations of medications. Adjusted survival plot was created to illustrate the rank order of two combined medications that affect the time from first occurrence of TBI to diagnosis of dementia with possible AD. Compared to those not taking any medication, patients taking metformin and statin (yellow) appear to develop dementia/AD faster. Except for those taking ACEI and metformin, ACEI and statin users (green) showed the most prolonged time from first occurrence of TBI to diagnosis of dementia with possible AD