Skip to main content
. 2020 Feb 27;10(5):766–788. doi: 10.1016/j.apsb.2020.02.008

Table 4.

Potential 3CLpro inhibitors from in-house natural product database.

No. Drug name Structure Pharmacological functions Source
1 (1S,2R,4aS,5R,8aS)-1-Formamido-1,4a-dimethyl-6-methylene-5-((E)-2-(2-oxo-2,5-dihydrofuran-3-yl)ethenyl)decahydronaphthalen-2-yl 5-((R)-1,2-dithiolan-3-yl) pentanoate Image 71 Anti-virus, anti-inflammatory effect Andrographolide derivatives
2 Betulonal Image 72 Anti-HIV-1 Cassine xylocarpa
3 Chrysin-7-O-β-glucuronide Image 73 Anti-virus, anti-inflammatory effect Scutellaria baicalensis
4 Andrographiside Image 74 Anti-virus, anti-inflammatory effect Andrographis paniculata
5 (1S,2R,4aS,5R,8aS)-1-Formamido-1,4a-dimethyl-6-methylene-5-((E)-2-(2-oxo-2,5-dihydrofuran-3-yl)ethenyl)decahydronaphthalen-2-yl 2-nitrobenzoate Image 75 Anti-virus, anti-inflammatory effect Andrographolide derivatives
6 2β-Hydroxy-3,4-seco-friedelolactone-27-oic acid Image 76 Anti-virus Viola diffusa
7 (S)-(1S,2R,4aS,5R,8aS)-1-Formamido-1,4a-dimethyl-6-methylene-5-((E)-2-(2-oxo-2,5-dihydrofuran-3-yl)ethenyl)decahydronaphthalen-2-yl-2-amino-3-phenylpropanoate Image 77 Anti-virus, anti-inflammatory effect Andrographolide derivatives
8 Isodecortinol Image 78 Anti-virus Viola diffusa
9 Cerevisterol Image 79 Anti-virus Viola diffusa
10 Hesperidin Image 80 Anti-inflammatory, anti-oxidant effect Citrus aurantium L.
11 Neohesperidin Image 81 Anti-tumor, anti-allergic effect Citrus aurantium L.
12 Andrograpanin Image 82 Anti-virus, anti-inflammatory effect Andrographis paniculata
13 2-((1R,5R,6R,8aS)-6-Hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethyl benzoate Image 83 Anti-virus, anti-inflammatory effect Andrographolide derivatives
14 Cosmosiin Image 84 Anti-inflammatory,
anti-oxidant, anti-HIV effect		 Scutellaria baicalensis
15 Cleistocaltone A Image 85 Anti-virus Cleistocalyx operculatus
16 2,2-Di(3-indolyl)-3-indolone Image 86 Anti-virus Isatis indigotica Fort.
17 Biorobin Image 87 Anti-virus Ficus benjamina
18 Gnidicin Image 88 Anti-tumor Gnidia lamprantha
19 Phyllaemblinol Image 89 Anti-virus Phyllanthus emblica
20 Theaflavin 3,3′-di-O-gallate Image 90 Anti-oxidant effect, anti-tumor,
anti-virus		 Camellia sinensis
21 Rosmarinic acid Image 91 Anti-viral,
anti-oxidant		 Salvia verticillata L.
22 Kouitchenside I Image 92 Anti-virus, anti-inflammatory effect Swertia kouitchensis
23 Oleanolic acid Image 93 Anti-virus, anti-inflammatory effect Swertia kouitchensis
24 Stigmast-5-en-3-ol Image 94 Anti-virus, anti-inflammatory effect Swertia binchuanensis
25 Deacetylcentapicrin Image 95 Anti-virus, anti-inflammatory effect Swertia macrosperma
26 Berchemol Image 96 Anti-virus, anti-inflammatory effect Swertiabi maculata